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A trial showed an AI risk score sped up autoimmune diagnoses

In a Vanderbilt randomized trial of nearly 2,000 analyzed patients with positive ANA tests, flagging high-risk patients for fast-track rheumatology referral cut the median time to diagnosis from 138 days to 43. The study is in NEJM AI and was supported by the NIH.

Verified · Source: Vanderbilt Health NewsNov 11, 2026 · 1 min read
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A clinical teaching room with exam tables, laptops, and a few people working
Illustrative photo of a clinical teaching lab. This is not the Vanderbilt trial. Mikepascoe / Wikimedia Commons · CC0 1.0

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The reporting lives at Vanderbilt Health News. Our summary is checked against it, and we link it on every story.

A randomized trial at Vanderbilt found that a transparent AI risk score, paired with a fast-track referral to rheumatology, shortened the wait for an autoimmune diagnosis, Vanderbilt Health News reported. Among nearly 2,000 analyzed patients who already had a positive ANA test, flagging the high-risk patients cut the median time to diagnosis from 138 days to 43. The study is published in NEJM AI and was supported by the National Institutes of Health. The 43 and 138 figures are medians in this group of patients. The result is a faster diagnosis, not a treatment and not a cure, and it applies to the patients in the trial.

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